Preferred Label : Milk Thistle;
NCIt definition : A substance derived from any of several Old World coarse prickly-leaved shrubs and
subshrubs including the plant Silybum marianum. Milk thistle's active chemical component
is silymarin, which is a combination of flavonoids such as silibinin, dehydrosilibinin,
silychristin and silydianin. These compounds are antioxidants and may alter the membrane
structure of the liver cell, thereby blocking the absorption of toxins; they may also
stimulate the production of new liver cells. In addition, milk thistle may increase
cellular adenosine triphosphate (ATP) levels, exhibiting dose-dependent cardiac myocyte
cytoprotection against doxorubicin. The silibinin component of milk thistle has been
shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling,
thereby inhibiting tumor growth. (NCI04);
Alternative definition : NCI-GLOSS: A plant that has been used in some cultures to treat certain medical problems,
including stomach, liver, and gallbladder disorders. The active extract of milk thistle
seeds is called silymarin. It is being studied in the prevention of liver damage caused
by some cancer treatments.;
UNII : U946SH95EE;
CAS number : 65666-07-1;
Codes from synonyms : CDR0000305993;
Origin ID : C29261;
UMLS CUI : C0937640;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
