NCIt definition : The oxide salt of magnesium with antacid, laxative and vascular smooth muscle relaxant
activities. Magnesium combines with water to form magnesium hydroxide which reacts
chemically to neutralize or buffer existing quantities of stomach acid; stomach-content
and intra-esophageal pH rise, resulting in a decrease in pepsin activity. This agent's
laxative effect is the result, in part, of osmotically mediated water retention, which
subsequently stimulates peristalsis. In addition, magnesium ions may behave as calcium
antagonists in vascular smooth muscle.;