NCIt definition : The citrate salt of the element magnesium with cathartic activity. The cathartic action
of magnesium cations appears to result, in part, from osmotically mediated water retention,
which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate
the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid
proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate
intestinal secretion via prostaglandin- and cyclic GMP-dependent mechanisms while
PAF produces significant stimulation of colonic secretion and gastrointestinal motility.;