Preferred Label : Monoclonal Antibody 96.5 F(ab);
NCIt synonyms : MOAB 96.5 FAB; 96.5 FAB; Monoclonal Antibody 96 5 F ab;
NCIt definition : A monovalent Fab fragment of the mouse monoclonal antibody (MoAb) 96.5, raised against
an epitope from human melanoma-associated cell surface marker p97. MoAb 96.5 Fab fragments
are composed of one constant and one variable domain of each of the heavy and the
light chain which together shape the antigen binding site at the amino terminal end
of the monomer. MoAb 96.5 Fab fragments are obtained through papain digestion in the
presence of cysteine. The advantage of using MoAb 96.5 Fab fragments over whole antibodies
is that they have reduced immunogenicity, better penetration of tissues, rapid clearance
from the body and that they do not induce precipitation.;
Origin ID : C29206;
UMLS CUI : C1513430;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
