Preferred Label : Monoclonal Antibody 1F5;
NCIt synonyms : Anti-CD20 Monoclonal Antibody 1F5; MOAB 1F5;
NCIt definition : A murine monoclonal antibody directed against CD20, a cross-membrane ion channel phosphoprotein
expressed by B cells, with potential antineoplastic activity. MOAB 1F5 binds to CD20,
thereby directly inhibiting B-cell proliferation and differentiation. When cross-linked
by secondary anti-mouse antibodies or Fc receptor-bearing cells, MOAB 1F5 may induce
activation of B-cell protein tyrosine kinases, increases in B-cell intracellular calcium
ion concentrations, and B-cell caspase activation, resulting in apoptosis of B cells
expressing CD20. (NCI04);
Origin ID : C29198;
UMLS CUI : C1513414;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
