Mitindomide - CISMeF

Preferred Label : Mitindomide;

NCIt synonyms : 4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-;

NCIt definition : A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis. This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04);

UNII : DK61ZER6T7;

InChIKey : DRCJGCOYHLTVNR-ZUIZSQJWSA-N;

CAS number : 10403-51-7;

Chemical formula : C14H12N2O4;

NSC code : 284356;

Details

Origin ID

C29195;

UMLS CUI

C0066593;

Currated CISMeF NLP mapping
- mitindomide [MeSH concept]
- mitindomide [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mitindomide [MeSH concept]
- mitindomide [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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