Preferred Label : MAGE-1 Vaccinia Contaminated with BVDV;
NCIt synonyms : MAGE-1 VACCINIA CONTAM BVDV;
NCIt definition : A cancer vaccine consisting of a recombinant vaccinia virus encoding the tumor-associated
gene MAGE-1 that is contaminated with bovine viral diarrhea virus (BVDV). The MAGE-1
gene is a member of the melanoma antigen-encoding gene family which is expressed in
various malignant tumors such as hepatocellular carcinoma and germ cell tumors in
addition to melanoma. Vaccination with vaccinia virus expressing human MAGE-1 may
generate antitumoral T-cell responses. BVDV is an RNA pestivirus that may contaminate
vaccines due to its presence in the fetal calf serum used as a growth supplement in
the tissue culture of mammalian cells used in vaccine production. (NCI04);
Origin ID : C29187;
UMLS CUI : C1518099;
Semantic type(s)
- concept_is_in_subset
