Preferred Label : Losartan/Hydrochlorothiazide;
NCIt synonyms : Losartan Hydrochlorothiazide; Losartan Potassium/Hydrochlorothiazide;
NCIt definition : A combination preparation of a synthetic angiotensin II antagonist and a diuretic
thiazide, with antihypertensive activity. Losartan, and its metabolite, selectively
and competitively block the binding of angiotensin II to the angiotensin II (AT1)
receptor. As a result, angiotensin II-AT1 mediated physiological effects such as vasoconstriction
and stimulation of aldosterone synthesis and secretion, which regulates extracellular
sodium concentration, are blocked. Hydrochlorothiazide inhibits electrolytes reabsorption
via binding to Na-Cl cotransporter on the renal distal tubular, thereby increasing
excretion of sodium, potassium, chloride, bicarbonate and water. Both agents lead
to a reduction in blood pressure.;
Drug name : Hyzaar;
Origin ID : C29166;
UMLS CUI : C0717825;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
