Preferred Label : Imexon;
NCIt synonyms : 4-imino-1,3-diazabicyclo[3,1,0]-hexan-2-one;
NCIt related terms : Amplimexon;
NCIt definition : A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although
its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway
involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms
of action of this agent may involve thiol depletion, generation of reactive oxygen
species (ROS), and decreases in the mitochondrial membrane potential. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of some types of cancer,
including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs
to the family of drugs called cyanoaziridine derivatives.;
UNII : 8F63U28T2V;
InChIKey : BIXBBIPTYBJTRY-UHFFFAOYSA-N;
CAS number : 59643-91-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 59643-91-3
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G-SRS /a ;
Drug name : Amplimexon;
Chemical formula : C4H5N3O;
NSC code : 714597;
Codes from synonyms : CDR0000513068; CDR0000471783;
Origin ID : C29115;
UMLS CUI : C0097147;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
