NCIt definition : A combination preparation of the analgesic acetaminophen and the semisynthetic opioid
agonist hydrocodone with analgesic and antitussive activities. Acetaminophen exerts
its analgesic activity by inhibiting prostaglandin synthesis while hydrocodone exerts
its analgesic activity by binding to the mu-receptors in the central nervous system
(CNS), thereby mimicking the effects of endogenous opioids.;