NCIt definition : A glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory
tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits
efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces
the viscosity of mucus secretion by reducing adhesiveness and surface tension as well
as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary
mechanism important in removing accumulated secretions from the upper and lower airway.;