Gemfibrozil - CISMeF

Preferred Label : Gemfibrozil;

NCIt definition : A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).;

UNII : Q8X02027X3;

InChIKey : HEMJJKBWTPKOJG-UHFFFAOYSA-N;

CAS number : 25812-30-0;

Drug name : Lopid;

Chemical formula : C15H22O3;

ChEBI ID : CHEBI:5296;

Codes from synonyms : 06549;

Details

Origin ID

C29071;

UMLS CUI

C0017245;

See also inter- (CISMeF)
- Product containing gemfibrozil (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Gemfibrozil [ICD-11 Extension code]
- Gemfibrozil [LOINC component]
- Gemfibrozil (substance) [SNOMED CT concept]
- Product containing gemfibrozil (medicinal product) [SNOMED CT concept]
- gemfibrozil [ATC Code]
- gemfibrozil [Substance BNPC]
- gemfibrozil [MeSH concept]
- gemfibrozil [SNOMED Notion]
- gemfibrozil [MeSH Descriptor]
Validated automatic mappings to BTNT
- gemfibrozil [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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