NCIt definition : A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome
proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation
of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This
enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein
C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent
reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In
addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression
results in an increase in high-density lipoprotein cholesterol (HDL-C).;