" /> Gemfibrozil - CISMeF





Preferred Label : Gemfibrozil;

NCIt definition : A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).;

UNII : Q8X02027X3;

InChIKey : HEMJJKBWTPKOJG-UHFFFAOYSA-N;

CAS number : 25812-30-0;

Drug name : Lopid;

Chemical formula : C15H22O3;

ChEBI ID : CHEBI:5296;

Codes from synonyms : 06549;

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28/05/2025


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