Preferred Label : Fenofibrate;
NCIt related terms : TriCor; Lofibra;
NCIt definition : A synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.
Fenofibrate is hydrolyzed in vivo to its active metabolite fenofibric acid that binds
to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting
in the activation of lipoprotein lipase and reduction of the production of apoprotein
C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall
in plasma triglycerides, in turn, leads to the modification of the small, dense low
density lipoporotein (LDL) particles into larger particles that are catabolized more
rapidly due to a greater affinity for cholesterol receptors. In addition, activation
of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density
lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL
cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein
(VLDL) while increasing HDL cholesterol.;
Alternative definition : NCI-GLOSS: A drug used to treat high levels of cholesterol and triglycerides in the
blood. Fenofibrate is being studied in the treatment of advanced cancers in young
patients and in the treatment of other conditions. It is a type of antilipidemic agent.;
UNII : U202363UOS;
InChIKey : YMTINGFKWWXKFG-UHFFFAOYSA-N;
CAS number : 49562-28-9;
Drug name : Tricor;
Chemical formula : C20H21ClO4;
ChEBI ID : CHEBI:5001;
Codes from synonyms : CDR0000539530; CDR0000539483; CDR0000518309;
Origin ID : C29047;
UMLS CUI : C0033228;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
