Preferred Label : Divalproex Sodium;
NCIt synonyms : Valproate Semisodium; Sodium Hydrogen Bis(2-propylpentanoate); Sodium Divalproex; Divalproex;
NCIt definition : A stable coordination compound comprised of sodium valproate and valproic acid with
anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate
ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric
acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing
brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block
the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing
repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.;
UNII : 644VL95AO6;
InChIKey : MSRILKIQRXUYCT-UHFFFAOYSA-M;
CAS number : 76584-70-8;
Drug name : Depakote; Epilex; Valparin; Epival; Depakote ER;
Molecule name : Abbott 50711;
Chemical formula : 2C8H15O2.H.Na;
ChEBI ID : CHEBI:4667;
Origin ID : C28996;
UMLS CUI : C0886883;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
