Divalproex Sodium

Preferred Label : Divalproex Sodium;

NCIt synonyms : Valproate Semisodium; Sodium Hydrogen Bis(2-propylpentanoate); Sodium Divalproex; Divalproex;

NCIt definition : A stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.;

UNII : 644VL95AO6;

InChIKey : MSRILKIQRXUYCT-UHFFFAOYSA-M;

CAS number : 76584-70-8;

Drug name : Depakote; Epilex; Valparin; Epival; Depakote ER;

Molecule name : Abbott 50711;

Chemical formula : 2C8H15O2.H.Na;

ChEBI ID : CHEBI:4667;

Details

Origin ID

C28996;

UMLS CUI

C0886883;

Automatic exact mappings (from CISMeF team)
- 2-propylvaleric acid [Substance BNPC]
- Divalproex [ICD-11 Extension code]
- Divalproex [ICHI extension code]
- hair removal [MeSH Descriptor]
- valproic acid [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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