NCIt definition : An ethanolamine and first-generation histamine antagonist with anti-allergic activity.
Dimenhydrinate competitively blocks H1 receptors, thereby preventing the actions of
histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth
muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased
capillary permeability, GI smooth muscle spasm.;