Preferred Label : Anti-Dopamine-b-Hydroxylase Monoclonal Antibody-Saporin;
NCIt synonyms : DSAP;
NCIt definition : An immunoconjugate of the anti-dopamine-b-hydroxylase monoclonal antibody covalently
linked to the ribosome-inactivating protein (RIP) saporin derived from Saponaria officinalis.
The monoclonal antibody component recognizes and attaches to the membrane-associated
antigen, dopamine-b-hydroxylase, resulting in the conjugate being internalized by
receptor-mediated endocytosis. The saporin toxin is then released from the complex,
and binds to ribosomal subunits, thereby halts protein synthesis, and results in cell
death. This immunoconjugate targets the dopamine-beta-hydroxylase enzyme localized
on adrenergic nerves in the brainstem particular medulla and pons, thereby could be
used to study neurodegenerative disorders and/or address fundamental neurobiological
questions.;
Origin ID : C28966;
UMLS CUI : C1510925;
False automatic mappings
- Semantic type(s)
