Preferred Label : Diacetylmorphine Hydrochloride;
NCIt synonyms : Heroine Hydrochloride; Diamorphine Hydrochloride; Heroin Hydrochloride; Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, Morphine, Diacetate
(ester), Hydrochloride;
NCIt related terms : DIAMORPHINE HYDROCHLORIDE ANHYDROUS;
NCIt definition : The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally
occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.). Once
administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine
(6-MAM) and then to the end-product morphine which binds to opiate receptors located
throughout the mammalian nervous and gastrointestinal systems. Inducing a potent analgesia,
the use of diamoprhine is often escalated due to a tolerance effect, resulting in
abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic
infections, among other adverse effects. (NCI04);
UNII : 8H672SHT8E;
InChIKey : FZJYQGFGNHGSFX-PVQKIFDLSA-N;
CAS number : 1502-95-0;
Chemical formula : C21H23NO5.HCl;
NSC code : 302357;
Origin ID : C28958;
UMLS CUI : C0282128;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
