" /> Cytochlor - CISMeF





Preferred Label : Cytochlor;

NCIt definition : A radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of radiosensitizer.;

UNII : J14D49ZN55;

InChIKey : NGGRGTWYSXYVDK-RRKCRQDMSA-N;

CAS number : 32387-56-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 32387-56-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

NSC code : 371331;

Codes from synonyms : CDR0000367441;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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