NCIt definition : The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic
and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA)
for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation
of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial
smooth muscle. This agent also competes with free serotonin for binding at serotonin
receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and
has been shown to stimulate appetite and weight gain. (NCI04);