Chloral Hydrate

Preferred Label : Chloral Hydrate;

NCIt definition : A synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.;

UNII : 418M5916WG;

InChIKey : RNFNDJAIBTYOQL-UHFFFAOYSA-N;

CAS number : 302-17-0;

Chemical formula : C2H3Cl3O2;

ChEBI ID : CHEBI:28142;

Details

Origin ID

C28922;

UMLS CUI

C0008161;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 2,2,2-trichloroethane-1,1-diol [Substance BNPC]
- Chloral hydrate [ICD-11 Extension code]
- Chloral hydrate [LOINC component]
- Chloral hydrate (substance) [SNOMED CT concept]
- Product containing chloral hydrate (medicinal product) [SNOMED CT concept]
- chloral hydrate [ATC Code]
- chloral hydrate [MeSH concept]
- chloral hydrate [MeSH Descriptor]
- chloral hydrate [SNOMED Notion]
Validated automatic mappings to BTNT
- chloral hydrate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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