Preferred Label : Cefuroxime Axetil;
NCIt synonyms : Cefurexine Axetil;
NCIt definition : A second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with
bactericidal activity. Cefuroxime's effect is dependent on its binding to penicillin-binding
proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in
the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of
the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting
consequent synthesis of peptidoglycan chains. As a result, cefuroxime inhibits bacterial
septum and cell wall synthesis formation.;
UNII : Z49QDT0J8Z;
InChIKey : KEJCWVGMRLCZQQ-YJBYXUATSA-N;
CAS number : 64544-07-6;
Chemical formula : C20H22N4O10S;
Origin ID : C28918;
UMLS CUI : C0055015;
Manual NTBT mappings (CISMeF)
- Semantic type(s)
- concept_is_in_subset
