NCIt definition : The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin
antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding
proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate
in the terminal stages of assembling the bacterial cell wall, and in reshaping the
cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage
of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This
results in the weakening of the bacterial cell wall and causes cell lysis.;