Preferred Label : Candesartan Cilexetil;
NCIt definition : A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with
antihypertensive activity. After hydrolysis of candesartan cilexetil to candesartan
during gastrointestinal absorption, candesartan selectively competes with angiotensin
II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth
muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation.
In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated
aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion
increase, followed by a reduction in plasma volume and blood pressure.;
UNII : R85M2X0D68;
InChIKey : GHOSNRCGJFBJIB-UHFFFAOYSA-N;
CAS number : 145040-37-5;
Drug name : Atacand; Blopress;
Chemical formula : C33H34N6O6;
Codes from synonyms : 09125;
Origin ID : C28903;
UMLS CUI : C0527379;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
