NCIt definition : A cyclic sulfonate ester with potential antineoplastic activity. As an alkylating
agent, clyclodisone induces the formation of DNA interstrand crosslinks, DNA strand
breaks, and alkali-labile lesions in the DNA of some tumor cell lines. Alkylating
agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to
DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04);