Anti-TAG-72 Monoclonal Antibody scFV CC-49/218

Preferred Label : Anti-TAG-72 Monoclonal Antibody scFV CC-49/218;

NCIt synonyms : CC49-218 sFv;

NCIt definition : An immunoglobulin derived from the single-chain antigen-binding domain (sFv) of the monoclonal antibody CC-49 with potential antineoplastic activity. The parent monoclonal antibody CC-49 binds to the tumor-associated glycoprotein TAG-72 with high affinity, recognizing many tumor cell types that express TAG-72. Because of its single-chain structure, CC-49/218 sFv may exhibit a longer half-life than the parent monoclonal antibody CC-49; 218 represents the linker sequence that helps reduce aggregation and proteolysis of this agent. (NCI04);

NCIt note : Single-chain Fv construct of CC49 monoclonal antibody containing a linker sequence 218 that targets tumor-associated glycoprotein (TAG)-72;

Details

Origin ID

C28880;

UMLS CUI

C4764299;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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