NCIt definition : A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics.
In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive
sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake
thus, decreasing the internal chloride concentration in neurons and may block the
excitatory effect of GABA in neonates.;