Preferred Label : Bcl-Xs Adenovirus Vaccine;
NCIt definition : A vaccine consisting of replication-defective recombinant adenovirus that encodes
for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus
vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in
decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function
of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid
tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04);
NSC code : 689513;
Origin ID : C28860;
UMLS CUI : C1511078;
Semantic type(s)
- concept_is_in_subset
