" /> Argatroban - CISMeF





Preferred Label : Argatroban;

NCIt synonyms : Argipidine; 1-[5-guanidino-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methyl-piperidine-2-carboxylic acid;

NCIt definition : A synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited.;

UNII : IY90U61Z3S;

InChIKey : AIEZTKLTLCMZIA-CZSXTPSTSA-N;

CAS number : 141396-28-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 141396-28-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : MD-805;

ChEBI ID : CHEBI:48720;

Codes from synonyms : 43;

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Keyword's position in hierarchy(ies) : arborescence

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21/05/2024


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