" /> Sultamicillin - CISMeF





Preferred Label : Sultamicillin;

NCIt synonyms : Ampicillin Sodium-Sulbactam Sodium;

NCIt definition : A combination formulation of the sodium salts of the antibiotic ampicillin and the beta-lactamase inhibitor sulbactam with antibacterial activity. Ampicillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. The sulbactam component irreversibly binds to bacterial beta-lactamase at or near its active site, thereby interfering with substrate binding and inhibiting bacterial metabolism of penicillin and cephalosporin beta-lactam antibiotics, effectively extending their antibiotic spectrum to include many beta-lactam-resistant bacteria.;

UNII : 65DT0ML581;

InChIKey : OPYGFNJSCUDTBT-PMLPCWDUSA-N;

CAS number : 76497-13-7;

Drug name : Unasyn;

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28/05/2025


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