Acetazolamide - CISMeF

Preferred Label : Acetazolamide;

NCIt synonyms : N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide;

NCIt related terms : N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide;

NCIt definition : A sulfonamide derivative with diuretic, antiglaucoma, and anticonvulsant properties. Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme found in cells in the proximal tube of the kidney, the eye, and glial cells. Inhibition of this enzyme in the kidney prevents excretion of hydrogen, leading to increased bicarbonate and cation excretion and increased urinary volume, which results in an alkaline diuresis. Acetazolamide reduces the concentration of bicarbonate, resulting in a decreased synthesis of aqueous humor in the eye, thereby lowering intraocular pressure. Although its mechanism of action is unknown, acetazolamide has anti-convulsant properties resulting from indirect effects secondary to metabolic acidosis or direct effects on neuronal transmission. Acetazolamide also produces respiratory stimulant effects in response to changes to both carbon dioxide and oxygen tension levels within the lungs.;

UNII : O3FX965V0I;

InChIKey : BZKPWHYZMXOIDC-UHFFFAOYSA-N;

CAS number : 59-66-5;

Drug name : Diluran; Diacarb;

Chemical formula : C4H6N4O3S2;

NSC code : 145177;

ChEBI ID : CHEBI:27690;

Codes from synonyms : 02221; 6021;

Details

Origin ID

C28809;

UMLS CUI

C0000981;

False automatic mappings
- Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics [ICD-10 Sub-category]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Acetazolamide [ICD-11 Extension code]
- Acetazolamide [LOINC component]
- Acetazolamide (substance) [SNOMED CT concept]
- Product containing acetazolamide (medicinal product) [SNOMED CT concept]
- acetazolamide [ATC Code]
- acetazolamide [Substance BNPC]
- acetazolamide [MeSH Descriptor]
- acetazolamide [MeSH concept]
- acetazolamide [SNOMED Notion]
Validated automatic mappings to BTNT
- acetazolamide [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Acetazolamide Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Acetazolamide Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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