" /> 8-Azaguanine - CISMeF





Preferred Label : 8-Azaguanine;

NCIt synonyms : 5-Amino-1H-v-triazolo(d)pyrimidin-7-ol; Triazologuanine; 8 AG; Guanazolo; Pathocidin; 5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine; 5-Amino-1,4-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one; 8-Azaguanine;

NCIt definition : A purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine transglycosylase). Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation. 8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis. This agent inhibits tumor cell growth and stimulates cell differentiation. (NCI04);

UNII : Q150359I72;

InChIKey : LPXQRXLUHJKZIE-UHFFFAOYSA-N;

CAS number : 134-58-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 134-58-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SK 1150; SF-337;

Chemical formula : C4H4N6O;

NSC code : 749; 223526;

ChEBI ID : CHEBI:63486;

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12/05/2024


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