Recombinant 70-kD Heat-Shock Protein

Preferred Label : Recombinant 70-kD Heat-Shock Protein;

NCIt synonyms : 70-kD Heat-Shock Protein; Heat Shock Protein 70; HSP70; Therapeutic 70-kD Heat-Shock Protein;

NCIt definition : A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. (NCI04);

Details

Origin ID

C28696;

UMLS CUI

C1527149;

Automatic exact mappings (from CISMeF team)
- HSP70 Heat-Shock proteins [MeSH concept]
- Heat-shock protein family a (hsp70), member 4 [OMIM gene]
- hsp70 heat-shock proteins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
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- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
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- 70-kD Heat-Shock Protein/MUC-1 Antigen [NCIt concept]
- gp209-2M Antigen/Heat Shock Protein 70/OVA Bip Peptide/Tyrosinase Peptide [NCIt concept]

Keyword's position in hierarchy(ies) :

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