Preferred Label : Synchrovax SEM Plasmid DNA Vaccine;
NCIt synonyms : Synchrotope MA2M Plasmid DNA Vaccine;
NCIt definition : A bivalent DNA vaccine encoding epitopes for both Melan-A (MART-1) and tyrosinase
with potential antineoplastic activity. Synchrovax SEM plasmid DNA vaccine contains
a plasmid pSEM that encodes 4 epitopes: Melan-A (26-35), Melan-A (31-96), tyrosinase
(1-9), and tyrosinase (369-377). Both Melan-A and tyrosinase are tumor antigens associated
with melanoma. Vaccination with this plasmid DNA vaccine may induce both humoral and
cytotoxic lymphocyte (CTL) responses against cells expressing either or both of these
antigens, resulting in decreased tumor growth.;
Origin ID : C28549;
UMLS CUI : C1134580;
Semantic type(s)
- concept_is_in_subset
