NCIt definition : A group of agents that bind to endothelin receptors, thereby inhibiting the actions
of endothelins. Inhibition of endothelins may decrease tumor growth, progression,
and angiogenesis. (NCI04);
Alternative definition : NCI-GLOSS: A family of drugs that block the hormone endothelin and may prevent prostate
cancer from spreading to the bones. They may also prevent the growth and spread of
other types of cancer, including colorectal cancer.;