Lontucirev - CISMeF

Preferred Label : Lontucirev;

NCIt synonyms : E1B 55kDa mutant adenovirus dl1520; E1B-Attenuated Adenovirus; Lontucirev (Replicating Adenovirus);

NCIt related terms : ONYX-015;

NCIt definition : An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released viruses infect neighboring tumor cells, tripping a chain of lontucirev-mediated tumor cell cytotoxicity. (NCI04);

Alternative definition : NCI-GLOSS: A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged.;

UNII : F1F4B2ILM1;

CAS number : 437981-77-6;

Molecule name : CI-1042; ONYX-015; CI 1042;

NSC code : 688653;

Codes from synonyms : CDR0000045994;

Details

Origin ID

C2830;

UMLS CUI

C4764298;

See also inter- (CISMeF)
- ONYX015 [MeSH concept]
- dl1520 [MeSH Supplementary Concept]
Semantic type(s)
- Virus [UMLS semantic type]
UMLS correspondences (same concept)
- ONYX015 [MeSH concept]
- dl1520 [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Positive Regulation of Cytolytic Process [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Fluorouracil/ONYX-015 [NCIt concept]

Keyword's position in hierarchy(ies) :

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