Verapamil Hydrochloride

Preferred Label : Verapamil Hydrochloride;

NCIt related terms : ( -)-Verapamil hydrochloride;

NCIt definition : The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04);

UNII : V3888OEY5R;

InChIKey : DOQPXTMNIUCOSY-UHFFFAOYSA-N;

CAS number : 152-11-4;

Drug name : Verelan; Isoptin SR; Calan;

Chemical formula : C27H38N2O4.ClH;

NSC code : 657799; 272366;

ChEBI ID : CHEBI:53188;

Codes from synonyms : NSC0272366; NSC0657799; 1090;

Details

Origin ID

C2827;

UMLS CUI

C0700468;

Automatic exact mappings (from CISMeF team)
- verapamil [MeSH Descriptor]
Currated CISMeF NLP mapping
- Lekoptin [International Nonproprietary Name]
- Verapamil hydrochloride [SMS substance]
- Verapamil hydrochloride (substance) [SNOMED CT concept]
- verapamil hydrochloride [Substance BNPC]
- verapamil hydrochloride [MeSH concept]
- verapamil hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lekoptin [International Nonproprietary Name]
- Verapamil hydrochloride (substance) [SNOMED CT concept]
- verapamil hydrochloride [MeSH concept]
- verapamil hydrochloride [Substance BNPC]
- verapamil hydrochloride [SNOMED Notion]
Validated automatic mappings to NTBT
- verapamil [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Verapamil [NCIt concept]
is_component_of_chemotherapy_regimen
- VAD/v Regimen [NCIt concept]
is_salt_form_of
- Verapamil [NCIt concept]

Keyword's position in hierarchy(ies) :

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