" /> Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome - CISMeF





Preferred Label : Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome;

NCIt synonyms : Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Alkylating Agent-Related AML and MDS;

NCIt definition : Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.;

Neoplastic status : Malignant;

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30/07/2025


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