Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome

Preferred Label : Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome;

NCIt synonyms : Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Alkylating Agent-Related AML and MDS;

NCIt definition : Acute myeloid leukemias and myelodysplastic syndromes arising as a result of the mutagenic effect of alkylating agents that are used for the treatment of malignant tumors. Patients usually develop a myelodysplastic syndrome which may evolve to a higher grade myelodysplastic syndrome or acute myeloid leukemia. A minority of patients present with an acute myeloid leukemia. Clonal cytogenetic abnormalities are frequently present and usually are unbalanced translocations or deletions of chromosomes 5 and 7. Patients with acute myeloid leukemia usually do not respond to treatment and have an unfavorable clinical outcome.;

Neoplastic status : Malignant;

Details

Origin ID

C27913;

UMLS CUI

C1332234;

Currated CISMeF NLP mapping
- Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent (disorder) [SNOMED CT concept]
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent [ICD-11 More detail]
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent [ORDO Disease]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Bone Marrow Basophilia [NCIt concept]
- Bone Marrow Fibrosis [NCIt concept]
- Granulocytopenia [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Pancytopenia [NCIt concept]
- Ring Sideroblasts 15 Percent or More of Erythroid Precursors [NCIt concept]
- Thrombocytopenia [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia and myelodysplastic syndrome related to alkylating agent (disorder) [SNOMED CT concept]
- Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent [ORDO Disease]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Hypolobated Neutrophil [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neutrophil with Cytoplasmic Hypogranularity [NCIt concept]
disease_has_finding
- Chemotherapeutic Agent Toxicity [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Secondary Lesion [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 5 [NCIt concept]
- Human Chromosome 7 [NCIt concept]
disease_may_have_abnormal_cell
- Dysplastic Megakaryocyte [NCIt concept]
disease_may_have_associated_disease
- Anemia [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 5 [NCIt concept]
- Loss of Chromosome 7 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients