Preferred Label : Multicentric Castleman Disease;
NCIt synonyms : Multicentric Castleman's Disease; Multicentric Angiofollicular Lymphoid Hyperplasia; MCD; iMCD; Idiopathic Multicentric Castleman Disease;
NCIt definition : Castleman disease characterized by fever, generalized lymphadenopathy, hypergammaglobulinemia,
and dysfunction of multiple organs. Other signs and symptoms include anemia, thrombocytopenia,
hepatomegaly, peripheral neuropathy and pleural effusions. Morphologically, in the
majority of cases the lymph nodes show features of Castleman disease of the plasma
cell type. In a minority of cases, changes of Castleman disease of the hyaline-vascular
type are seen. In contrast to patients with localized disease who are usually cured
following resection of the lesion, patients with the multicentric form of the disease
may follow a progressive clinical course, complicated by infection, Kaposi sarcoma,
or lymphoma.;
Neoplastic status : Undetermined;
Origin ID : C27855;
UMLS CUI : C1334815;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Disease excludes normal cell origin
- Disease may have findings
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_may_have_associated_disease
