Preferred Label : Paclitaxel PPE Microspheres;
NCIt synonyms : Paclimer Microspheres (Polilactofate/Paclitaxel); Paclitaxel Biopolymer Formulation;
NCIt definition : A paclitaxel formulation containing paclitaxel incorporated in biodegradable polyphosphoester
(PPE) polymer form with potential antineoplastic activity. Upon intraperitoneal delivery,
paclitaxel PPE microspheres slowly and continuously dissolve and deliver paclitaxel
to the tumor site, where it binds to tubulin and inhibits the dynamics of disassembly-assembly
of microtubules. As a result, this formulation induces cell cycle arrest and leads
to cell death.;
Drug name : Paclimer Microspheres;
NSC code : 715074;
Origin ID : C2785;
UMLS CUI : C1518843;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
