" /> Anti-Thymocyte Globulin - CISMeF





Preferred Label : Anti-Thymocyte Globulin;

NCIt synonyms : Antithymocyte Serum; ATS; ATG;

NCIt related terms : antithymocyte globulin;

NCIt definition : Purified gamma globulin, with immunosuppressive activity. Obtained from animals that have been immunized with human thymocytes, antithymocyte globulin (ATG) specifically recognizes and destroys T lymphocytes. Although not completely understood, the mechanism of action appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host (GVH) disease.;

Alternative definition : NCI-GLOSS: Serum from blood that contains antibodies that bind to human T cells. Antithymocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD). It is also used to treat GVHD and after a kidney transplant to help keep the body from rejecting the kidney.;

Codes from synonyms : CDR0000045600;

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29/05/2025


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