Typical Acute Promyelocytic Leukemia

Preferred Label : Typical Acute Promyelocytic Leukemia;

NCIt synonyms : Hypergranular Acute Promyelocytic Leukemia;

NCIt definition : Acute Promyelocytic leukemia characterized by the presence of hypergranular promyelocytes and characteristic cells that contain bundles of Auer rods.;

Neoplastic status : Malignant;

Details

Origin ID

C27756;

UMLS CUI

C0349675;

Automatic exact mappings (from CISMeF team)
- leukemia, promyelocytic, acute [MeSH Descriptor]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Disseminated Intravascular Coagulation [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- RARA Gene Rearrangement [NCIt concept]
- t(15;17)(q24;q21) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Hypergranular promyelocytic leukemia (disorder) [SNOMED CT concept]
Validated automatic mappings to NTBT
- Acute promyelocytic leukemia [ORDO Disease]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Hypergranular Promyelocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neoplastic Promyelocyte [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Promyelocytes in Bone Marrow Markedly Increased [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
- PML-RARA Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- PML/RARA Fusion Gene [NCIt concept]
- RARA Gene [NCIt concept]
disease_may_have_abnormal_cell
- Faggot Cell [NCIt concept]

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