Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

Preferred Label : Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia;

NCIt synonyms : Topoisomerase II Inhibitor Related Acute Myeloid Leukemia; Topoisomerase II Inhibitor-Related AML;

NCIt definition : Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene).;

Neoplastic status : Malignant;

Details

Origin ID

C27755;

UMLS CUI

C1336769;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Cells of Monocytic Lineage 80 Percent or More of Bone Marrow Leukemic Cells [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
- Neoplastic Granulocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
- Neoplastic Monocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Blast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Chemotherapeutic Agent Toxicity [NCIt concept]
- Immature Myeloid Cells Increased in Bone Marrow [NCIt concept]
- Ineffective Hematopoiesis [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Secondary Lesion [NCIt concept]
- Therapy-Related Toxicity [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_may_have_abnormal_cell
- Neoplastic Monoblast [NCIt concept]
- Neoplastic Monocyte [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Neutrophilic Precursor [NCIt concept]
- Neoplastic Promonocyte [NCIt concept]
disease_may_have_cytogenetic_abnormality
- t(11;19)(q23.3;p13.1) [NCIt concept]
- t(9;11)(q21;q23) [NCIt concept]

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