Sinonasal Tract Angiofibroma

Preferred Label : Sinonasal Tract Angiofibroma;

NCIt synonyms : Nasopharyngeal Juvenile Angiofibroma; Sinonasal Angiofibroma; Nasopharyngeal Angiofibroma;

NCIt definition : A morphologic variant of fibroma with numerous dilated vascular channels that arises from the posterolateral wall of the roof of the nasal cavity or lateral nasopharynx. It is associated with somatic mutations in CTNNB1 gene in the majority of cases.;

Neoplastic status : Benign;

Details

Origin ID

C27479;

UMLS CUI

C1367536;

Automatic exact mappings (from CISMeF team)
- Angiofibroma, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Juvenile angiofibroma of nasopharynx (disorder) [SNOMED CT concept]
- Juvenile nasopharyngeal angiofibroma [HPO term]
Currated CISMeF NLP mapping
- Juvenile nasopharyngeal angiofibroma [ORDO Disease]
- Nasopharyngeal angiofibroma [MedDRA LLT]
- nasopharyngeal angiofibroma [Disease (Nov.)]
Disease excludes abnormal cell
- Giant Cell [NCIt concept]
- Malignant Cell [NCIt concept]
Disease excludes normal cell origin
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
Disease may have findings
- Dyspnea [NCIt concept]
- Epistaxis [NCIt concept]
- Headache [NCIt concept]
- Nasal Obstruction [NCIt concept]
- Tinnitus [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
- Maxillofacial Bone [NCIt concept]
Has associated anatomic sites
- Connective and Soft Tissue [NCIt concept]
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
- Sinonasal Tract [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Juvenile angiofibroma of nasopharynx (disorder) [SNOMED CT concept]
- Juvenile nasopharyngeal angiofibroma [ORDO Disease]
- Juvenile nasopharyngeal angiofibroma [HPO term]
- Nasopharyngeal angiofibroma [MedDRA LLT]
- nasopharyngeal angiofibroma [Disease (Nov.)]
disease_excludes_cytogenetic_abnormality
- Loss of Chromosome 11q [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 14q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 9p [NCIt concept]
- Loss of Chromosome 9q [NCIt concept]
disease_excludes_finding
- Infiltrative Growth Pattern [NCIt concept]
- Locally Aggressive Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_abnormal_cell
- Neoplastic Cell [NCIt concept]
- Neoplastic Connective and Soft Tissue Cell [NCIt concept]
- Neoplastic Fibroblast [NCIt concept]
- Neoplastic Spindle-Shaped Fibroblast [NCIt concept]
disease_has_finding
- Benign Cellular Infiltrate [NCIt concept]
- Fibrotic Stroma Formation [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Vascular Proliferation [NCIt concept]
- Well-Circumscribed Lesion [NCIt concept]
disease_has_normal_cell_origin
- Connective and Soft Tissue Cell [NCIt concept]
- Fibroblast [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
- Sinonasal Tract [NCIt concept]
disease_mapped_to_gene
- CTNNB1 Gene [NCIt concept]
disease_may_have_molecular_abnormality
- CTNNB1 Gene Mutation [NCIt concept]
pathogenesis_of_disease_involves_gene
- CTNNB1 Gene [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]

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