Vandetanib - CISMeF

Preferred Label : Vandetanib;

NCIt related terms : ZD6474; Zactima;

NCIt definition : An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of lung cancer and other types of cancer. It may block the growth and spread of tumor cells and prevent the growth of new blood vessels that tumors need to grow. Vandetanib is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.;

UNII : YO460OQ37K;

InChIKey : UHTHHESEBZOYNR-UHFFFAOYSA-N;

CAS number : 443913-73-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 443913-73-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zactima; Caprelsa; Lucivand;

Molecule name : AZD6474; ZD-6474;

Chemical formula : C22H24BrFN4O2;

ChEBI ID : CHEBI:49960;

Codes from synonyms : CDR0000549435; 50640; CDR0000530320; CDR0000285944; 529;

Details

Origin ID

C2737;

UMLS CUI

C1121849;

Automatic exact mappings (from CISMeF team)
- Vandetanib [ICD-11 Extension code]
- vandetanib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing vandetanib (medicinal product) [SNOMED CT concept]
- Vandetanib (substance) [SNOMED CT concept]
- vandetanib [MeSH Supplementary Concept]
- vandetanib [MeSH concept]
- vandetanib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Paclitaxel/ZD-6474 [NCIt concept]
- Docetaxel/Vandetanib Regimen [NCIt concept]
- Docetaxel/ZD6474 [NCIt concept]
- Vandetanib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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