" /> Vandetanib - CISMeF





Preferred Label : Vandetanib;

NCIt related terms : ZD6474; Zactima;

NCIt definition : An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of lung cancer and other types of cancer. It may block the growth and spread of tumor cells and prevent the growth of new blood vessels that tumors need to grow. Vandetanib is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.;

UNII : YO460OQ37K;

InChIKey : UHTHHESEBZOYNR-UHFFFAOYSA-N;

CAS number : 443913-73-3;

Drug name : Zactima; Caprelsa; Lucivand;

Molecule name : AZD 6474; ZD-6474; AZD-6474;

Chemical formula : C22H24BrFN4O2;

ChEBI ID : CHEBI:49960;

Codes from synonyms : CDR0000549435; 50640; CDR0000530320; CDR0000285944; 529;

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10/05/2025


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