" /> Vascular Disrupting Agent ZD6126 - CISMeF





Preferred Label : Vascular Disrupting Agent ZD6126;

NCIt synonyms : ZD6126; N-[(5S)-6,7-Dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide; N-acetylcochinol-O-phosphate;

NCIt related terms : ZD-6126;

NCIt definition : A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD-6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cell apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis.;

Alternative definition : NCI-GLOSS: A substance that has been studied in the treatment of several types of cancer. ZD6126 destroys blood vessels in tumors and may prevent the growth of new blood vessels that tumors need to grow. It is a type of vascular targeting agent and a type of antiangiogenesis agent.;

UNII : GBO3S6M9W7;

InChIKey : UGBMEXLBFDAOGL-INIZCTEOSA-N;

CAS number : 219923-05-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 219923-05-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ZD-6126; ANG453; ZM-445526;

Chemical formula : C20H24NO8P;

Codes from synonyms : CDR0000644375; 50639;

PubMed : 18219445;

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12/05/2024


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