Rhodacyanine Analog MKT-077

Preferred Label : Rhodacyanine Analog MKT-077;

NCIt synonyms : MKT-077; 1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chloride; Rhodacyanine;

NCIt related terms : 1-Ethyl-2-[[-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]pyridinium Chloride;

NCIt definition : A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function.;

UNII : 8PF5ZXI0JE;

CAS number : 147366-41-4;

Molecule name : FJ 776;

Codes from synonyms : 50274;

Details

Origin ID

C2731;

UMLS CUI

C0386286;

Automatic exact mappings (from CISMeF team)
- MKT 077 [MeSH concept]
- MKT 077 [MeSH Supplementary Concept]
- rhodacyanine [MeSH concept]
- rhodacyanine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 1-ethyl-2-((3-ethyl-5-(3-methylbenzothiazolin-2-yliden))-4-oxothiazolidin-2-ylidenemethyl)pyridium chloride [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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