NCIt related terms : 1-Ethyl-2-[[-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]pyridinium
Chloride;
NCIt definition : A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic
cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell
mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest
and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated
by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor
p53 function.;
UNII : 8PF5ZXI0JE;
CAS number : 147366-41-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 147366-41-4
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