Preferred Label : Radiolabeled CC49;
NCIt definition : A radioimmunoconjugate comprised of a humanized monoclonal antibody with antitumor
activity. The monoclonal antibody CC49 is developed from the murine monoclonal antibody
B72.3 and is humanized by grafting the hypervariable regions onto the variable light
(VL) and variable heavy (VH) frameworks of the monoclonal antibodies LEN and 21/28'
CL. The resultant antibody binds the pancarcinoma tumor-associated glycoprotein (TAG)-72
with high affinity. Furthermore, the antibody is commonly radiolabeled resulting in
an effective agent for use in radioimmunotherapy for treatment of cancer.;
Origin ID : C2729;
UMLS CUI : C1514701;
Semantic type(s)
- concept_is_in_subset
