" /> EGFR Inhibitor PD-168393 - CISMeF





Preferred Label : EGFR Inhibitor PD-168393;

NCIt synonyms : 4-[(3-Bromophenyl)amino]-6-Acrylamidoquinazoline;

NCIt related terms : PD-168393;

NCIt definition : A quinazolone compound with anti-tumor activity. PD-168393 is a cell-permeable, irreversible, and selective inhibitor of ligand-dependent epidermal growth factor (EGF) receptor (EGFR). This agent binds to the catalytic domain of EGFR with a 1:1 stoichiometry and inactivates the EGFR tyrosine kinase activity through alkylation of a cystine residue (Cys-773) within the ATP-binding pocket, thereby inhibiting proliferation of EGFR-expressing tumor cells.;

UNII : 3R996Y9T0I;

CAS number : 194423-15-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 194423-15-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PD 168 393;

Chemical formula : C17H13BrN4O;

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15/05/2024


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