NCIt definition : A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase
messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression
both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector
of Ras-mediated signal transduction; constitutive activation of this pathway directly
contributes to malignant transformation. (NCI04);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer.;
UNII : 48IAF3FDP3;
CAS number : 177075-18-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 177075-18-2
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G-SRS /a ;
Molecule name : ISIS-5132; ISIS 5132; CGP69846A; CGP 69846A;