c-raf Antisense Oligonucleotide ISIS 5132

Preferred Label : c-raf Antisense Oligonucleotide ISIS 5132;

NCIt synonyms : ISIS 5132/CGP69846A; RAF-IK Antisense ODN; c-RAF Antisense;

NCIt related terms : ISIS-5132; ISIS 5132;

NCIt definition : A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer.;

UNII : 48IAF3FDP3;

CAS number : 177075-18-2;

Molecule name : ISIS-5132; ISIS 5132; CGP69846A; CGP 69846A;

NSC code : 719336;

Codes from synonyms : CDR0000045965;

Details

Origin ID

C2721;

UMLS CUI

C4764297;

See also inter- (CISMeF)
- ISIS 5132 [MeSH concept]
- ISIS 5132 [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ISIS 5132 [MeSH concept]
- ISIS 5132 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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