Telomerase Inhibitor FJ5002

Preferred Label : Telomerase Inhibitor FJ5002;

NCIt definition : A derivative of rhodacyanine with potential antineoplastic activity. FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells. Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04);

Molecule name : FJ5002;

Details

Origin ID

C2715;

UMLS CUI

C0908717;

Automatic exact mappings (from CISMeF team)
- FJ 5002 [MeSH concept]
- FJ 5002 [MeSH Supplementary Concept]
- rhodacyanine [MeSH concept]
- rhodacyanine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FJ 5002 [MeSH concept]
- FJ 5002 [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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